| Project/Area Number |
16K18488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Murota Yukiko 東京大学, 大学院理学系研究科(理学部), 特任研究員 (30774707)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | piRNA / Yb body / Flam body / piRNA生合成 / PIWIタンパク質 / ゲノム / RNA / RNAサイレンシング |
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| Outline of Final Research Achievements |
In this study, it was intended to elucidate a function of protein located in Yb body and Flam body which were piRNA biosynthetic place. As a result, Vret and soYb protein which are localized in Yb body promote stabilization of the protein mutually by interacting directly. On the other hand, about the different factor called Armi, it was revealed that the interaction of it and Vret needs RNA. Furthermore, piRNA composed in Yb body establishes piRISC with Piwi . And then, piRISC combined with Importin alpha of transportation factor in the nucleus and was transported to the nucleus.
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