| Project/Area Number |
16K18492
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OKASHITA Naoki 徳島大学, 先端酵素学研究所(次世代), 助教 (10757933)
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| Research Collaborator |
TACHIBANA Makoto 徳島大学, 先端酵素学研究所, 教授 (80303915)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 性決定 / エピジェネティクス / Sry |
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| Outline of Final Research Achievements |
In mammals, the sex-determining gene Sry on the Y chromosome initiates testis differentiation in embryonic gonads. Sry expression in gonads is fine-tuned in both space and time. We previously demonstrated that Histone H3 lysine 9 (H3K9) demethylation Jmjd1a plays an indispensable role in mouse sex development. However, little is known about epigenetic regulators other than Jmjd1a responsible for regulation of Sry expression.
As a result of our analysis, methylcytosine dioxygenases (Tets), H3K9 methylases (Suv39h) and H3K9 methyl binders (HP1 family) played an important role in regulation of Sry expression.
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