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Analysis of a novel lncRNA that regulates human chromosome segregation

Research Project

Project/Area Number 16K18495
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionNational Institute of Genetics

Principal Investigator

Shiratsuchi Gen  国立遺伝学研究所, 分子遺伝研究系, 特任研究員 (80625533)

Research Collaborator KITAGAWA Daiju  国立遺伝学研究所, 分子遺伝研究系, 教授 (80605725)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsnon-coding RNA / noncoding RNA / 核酸 / 細胞生物学 / 分子生物学 / 細胞分裂
Outline of Final Research Achievements

Although long non-coding RNAs (lncRNAs) have been revealed to function in a wide range of biological phenomena, the lncRNAs that function in specific mitotic events are poorly understood yet. In this study, I characterized a novel human lncRNA, named CENNA1 (Centrosomal Non-coding RNA 1) that had been identified as a novel regulator of mitosis by our group. I found that depletion of CENNA1 significantly impaired the establishment of kinetochore-microtubule attachment, accompanied with the loss of CLIP170, a member of conserved microtubule plus-end tracking proteins, from the kinetochores. This study sheds light on the new aspect of lncRNA that controls chromosome segregation and would provide a new avenue to the future cell division research.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] ヒトの紡錘体形成を制御する新規lncRNA.2017

    • Author(s)
      白土 玄, 芦川 朋子, 吉場 聡子, 豊田 敦, 藤山 秋佐夫, 北川 大樹
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト紡錘体形成を制御する新規lncRNAの同定.2017

    • Author(s)
      白土 玄, 芦川 朋子, 吉場 聡子, 豊田 敦, 藤山 秋佐夫, 北川 大樹
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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