Chemical biology of small RNA chromatin modifiers

Research Project

Project/Area Number	16K18496
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Molecular biology
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	Schneider Tilman 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 研究員 (30599478)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	Chemical Biology / Splicing / epigenetics / splicing / chromatin / small RNA / エピジェネチックス / 生化学
Outline of Final Research Achievements	Splicing inhibition with the small molecule SSA leads to a small RNA-dependent increase in heterochromatin. High throughput sequencing displayed an increase in histone methylation. However, a close association with novel small RNA sequences could not be confirmed. Data refinement and partial re-sequencing is ongoing.