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Chemical biology of small RNA chromatin modifiers

Research Project

Project/Area Number 16K18496
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Schneider Tilman  国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 研究員 (30599478)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsChemical Biology / Splicing / epigenetics / splicing / chromatin / small RNA / エピジェネチックス / 生化学
Outline of Final Research Achievements

Splicing inhibition with the small molecule SSA leads to a small RNA-dependent increase in heterochromatin. High throughput sequencing displayed an increase in histone methylation. However, a close association with novel small RNA sequences could not be confirmed. Data refinement and partial re-sequencing is ongoing.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Along the Central Dogma Controlling Gene Expression with Small Molecules2018

    • Author(s)
      Schneider-Poetsch Tilman、Yoshida Minoru
    • Journal Title

      Annual Review of Biochemistry

      Volume: 87 Issue: 1 Pages: 1-30

    • DOI

      10.1146/annurev-biochem-060614-033923

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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