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Improving diffraction resolution of protein crystal by high pressure

Research Project

Project/Area Number 16K18502
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Structural biochemistry
Research InstitutionNagoya University

Principal Investigator

Nagae Takayuki  名古屋大学, シンクロトロン光研究センター, 特任助教 (90735771)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords圧力 / 水和 / 分解能 / 蛋白質結晶の分解能向上 / 蛋白質 / 生物物理
Outline of Final Research Achievements

In this study we researched relationship between diffraction resolution of protein crystals and high pressure. For several kinds of proteins, diffraction data of crystals were collected and analyzed. High pressure tended to improve diffraction resolution of proteins which have low molecular weight. The reason is considered that high pressure makes hydration structure ordered and as a result diffraction ability of entire crystal improve. High pressure could improve crystal resolution of proteins which have low molecular weight, regardless of kinds of proteins or crystallization conditions.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Presentation (9 results)

  • [Presentation] サーモライシンの高圧結晶構造解析2018

    • Author(s)
      永江峰幸,森一也,渡邉信久
    • Organizer
      第31回日本放射光学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サーモライシンの高圧結晶構造解析2018

    • Author(s)
      森一也,永江峰幸,渡邉信久
    • Organizer
      2017年度生物物理中部支部講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サーモライシンの高圧結晶構造解析2018

    • Author(s)
      永江峰幸,森一也,渡邉信久
    • Organizer
      第6回あいちシンクロトロン光センター事業成果発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高圧結晶構造解析によるサーモライシンの高エネルギー準安定構造の研究2018

    • Author(s)
      森一也,永江峰幸,渡邉信久
    • Organizer
      第7回名古屋大学シンクロトロン光研究センターシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加圧による蛋白質結晶の分解能向上2017

    • Author(s)
      永江峰幸,森一也,渡邉信久
    • Organizer
      日本放射光学会
    • Place of Presentation
      神戸芸術センター(兵庫県神戸市)
    • Year and Date
      2017-01-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 加圧による蛋白質結晶の分解能向上2017

    • Author(s)
      永江峰幸,森一也,渡邉信久
    • Organizer
      第30回日本放射光学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] タンパク質構造解析における高圧力の利用2017

    • Author(s)
      森一也,永江峰幸,渡邉信久
    • Organizer
      特殊環境微生物セミナー2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加圧によるタンパク質結晶の結晶性向上2017

    • Author(s)
      森一也,永江峰幸,渡邉信久
    • Organizer
      第58回高圧討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加圧による蛋白質結晶の結晶性向上2016

    • Author(s)
      永江峰幸,森一也,渡邉信久
    • Organizer
      日本結晶学会
    • Place of Presentation
      茨城県立県民文化センター(茨城県水戸市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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