| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Recent studies have shown that different organelles physically bind to each other to form an organelle contact site. Organelle contacts are physiologically important because they are associated with diseases such as neurodegenerative diseases, but their functions are not well understood. In this study, we investigated the function of the ERMES complex that physically binds mitochondria to endoplasmic reticulum (ER) and revealed that the ERMES complex plays an important role in transporting phospholipids between mitochondria and ER. We also showed that the ERMES complex is functionally related to the degree of lipid unsaturation.
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