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Identification of the novel neural mechanism for control of courtship vocalizations in male quail

Research Project

Project/Area Number 16K18585
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Animal physiology/Animal behavior
Research InstitutionAzabu University

Principal Investigator

Tobari Yasuko  麻布大学, 獣医学部, 講師 (90453919)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsノルアドレナリン / 求愛発声 / 鳥類 / ウズラ / 交尾行動 / 顔認知 / 異性の存在 / 雄叫び / 中脳発声中枢 / アドレナリン受容体 / 青斑核 / 地鳴き / 一目惚れ / 求愛行動 / 社会相互作用 / 視床下部-下垂体-生殖腺軸
Outline of Final Research Achievements

Social interactions rapidly modulate circulating hormone levels and behavioral patterns in most male animals. In male birds, sexual interaction or visual exposure to a conspecific female usually change the levels of peripheral reproductive hormones and behavioral patterns. Although the perception of a female presence is processed in the brain and peripheral hormonal levels are regulated by the hypothalamus-pituitary-gonadal (HPG) axis, the specific neural circuitry and neurochemical systems that translate social signals into reproductive physiology in male birds were not well understood. We investigated the male responses of a hypothalamic neuropeptide (GnIH) to the social environments, and identified the noradrenergic pathways linking visual perception of a potential mate to the changes in GnIH gene expression in the brain and modifying courtship vocalization of sexually mature male Japanese quail.

Academic Significance and Societal Importance of the Research Achievements

これまで異性との社会的相互作用に関わる重要な神経伝達物質は、報酬系との関連からドーパミンが注目されていた。しかしながら、研究者が行った一連の研究結果から異性認知から起こる個体の生理状態の変化や行動の変化には、注意、覚醒やストレスに関連するとされるノルアドレナリンが重要であることが示されました。ノルアドレナリンはストレスに加えて、衝動性やうつ病とも関連が深いホルモンであるという側面も持つ。現代社会では、対人関係などの社会的刺激による衝動的行動が問題となっているが、その神経化学的基盤の解明に本課題が貢献できるかもしれない。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results)

  • [Int'l Joint Research] the University of Edinburgh(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] The Roslin Institute/The University of Edinburgh(United Kingdom)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Effects of Social Information on the Release and Expression of Gonadotropin-Inhibitory Hormone in Birds2019

    • Author(s)
      Tobari Y, Tsutsui K.
    • Journal Title

      Frontiers in Endocrinology

      Volume: 10 Pages: 243-243

    • DOI

      10.3389/fendo.2019.00243

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Female Japanese quail visually differentiate testosterone-dependent male attractiveness for mating preferences2018

    • Author(s)
      Hiyama Gen、Mizushima Shusei、Matsuzaki Mei、Tobari Yasuko、Choi Jae-Hoon、Ono Takashi、Tsudzuki Masaoki、Makino Satoshi、Tamiya Gen、Tsukahara Naoki、Sugita Shoei、Sasanami Tomohiro
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 10012-10012

    • DOI

      10.1038/s41598-018-28368-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noradrenergic modulation of gonadotrophin-inhibitory hormone gene expression in the brain of Japanese quail.2017

    • Author(s)
      Tobari Y, Kansaku N, Tsutsui K.
    • Journal Title

      J Neuroendocrinol.

      Volume: 29(8) Issue: 8 Pages: 1-8

    • DOI

      10.1111/jne.12503

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hormonal responses to a potential mate in male birds2017

    • Author(s)
      Tobari Y, Sato Y, Okanoya K
    • Journal Title

      Adv Exp Med Biol

      Volume: 1001 Pages: 137-149

    • DOI

      10.1007/978-981-10-3975-1_9

    • ISBN
      9789811039744, 9789811039751
    • URL

      https://pure.teikyo.jp/en/publications/5761f0a8-9163-4339-8765-c2f9e239fd75

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hormonal responses to a potential mate in male birds2017

    • Author(s)
      Yasuko Tobari, Yoshimi Sato, Kazuo Okanoya
    • Journal Title

      Advances in experimental medicine and biology

      Volume: 1001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of Vasoactive Intestinal Polypeptide and Forskolin on mRNA Expression of Prolactin and Prolactin Regulatory Element-Binding Protein in the Anterior Pituitary Gland of Chicken Embryo and Laying Hens2016

    • Author(s)
      Norio Kansaku, Yasuko Tobari, Gen Hiyama, Shin Wakui, Naokazu Minoguchi, Masazumi Numata, Katsutoshi Kino, David Zadworny
    • Journal Title

      The Journal of Poultry Science

      Volume: 53 Issue: 4 Pages: 313-317

    • DOI

      10.2141/jpsa.0160039

    • NAID

      130005433056

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 異なる社会環境でのノルアドレナリンによる生殖内分泌系と求愛行動の調節2018

    • Author(s)
      戸張靖子
    • Organizer
      第29回日本行動神経内分泌研究会 比較内分泌シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ノルアドレナリンによる雄ウズラの求愛発声の調節2018

    • Author(s)
      戸張靖子, 原田倫圭, 増澤杏実, 神作宜男
    • Organizer
      第42回鳥類内分泌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ニワトリ発生胚下垂体におけるプロラクチン分子検出2018

    • Author(s)
      神作宜男 戸張靖子 笹浪知宏
    • Organizer
      日本家禽学会2018年度春季大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Hormonal and behavioral responses to a potential mate in birds. Japan-China young women scientists symposium2017

    • Author(s)
      Tobari Y.
    • Organizer
      日中女性若手研究者会議
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 雌ウズラの配偶者選択に関する研究2017

    • Author(s)
      檜山源 政森楓 戸張靖子 松崎芽衣 笹浪知宏
    • Organizer
      雌ウズラの配偶者選択に関する研究
    • Related Report
      2017 Research-status Report
  • [Presentation] 異なる社会環境でのノルアドレナリンによる視床下部 GnIH 遺伝子発現調節2017

    • Author(s)
      戸張靖子 神作宜男 筒井和義
    • Organizer
      第 41 回 鳥類内分泌研究会東京大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ウズラ脳におけるGnIH遺伝子発現のノルアドレナリンの調節2017

    • Author(s)
      戸張靖子 神作宜男 筒井和義
    • Organizer
      日本動物学会 第88回
    • Related Report
      2017 Research-status Report
  • [Presentation] A new pathway mediating social effects on the endocrine system: Female presence acting via norepinephrine release stimulates gonadotropin-inhibitory hormone in the paraventricular nucleus and suppresses luteinizing hormone in quail.2016

    • Author(s)
      Yasuko Tobari
    • Organizer
      The 22nd International congress of zoology, the 87th meeting of zoological society of japan.
    • Place of Presentation
      沖縄科学技術大学院大学 (沖縄県国頭郡恩納村)
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 遺伝子から解き明かす性の不思議な世界 ( 第5章 鳥の性 )2019

    • Author(s)
      戸張靖子
    • Total Pages
      544
    • Publisher
      一色出版
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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