Evolution of genome and metagenome association in primates
| Project/Area Number |
16K18630
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical anthropology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
Hirata Satoshi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 霊長類 / ゲノム / メタゲノム / 腸内細菌叢 / 口腔細菌叢 / 共進化 / チンパンジー / 動物福祉 / 次世代シークエンサー / 細菌叢 / ゲノム多様性 / 腸内細菌 |
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| Outline of Final Research Achievements |
This study aimed to elucidate the genome and metagenome association in captive and wild primates. Fecal samples of about 50 captive chimpanzees in Kyoto University were collected and subject to 16S rRNA sequencing analysis for symbiont gut bacteria. Relationship between individual background (especially genomic polymorphisms) and 16S diversity was analyzed. Fecal and oral bacterial samples of many primate species in Japan Monkey Centre and some field areas were collected for analysis of metagenomic profile in terms of species specificity and phylogenetic constraint.
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| Academic Significance and Societal Importance of the Research Achievements |
ゲノムとメタゲノムは哺乳類をはじめとする多細胞生物の生命活動の根幹を支えるが、その両者の連関についての理解はまだ乏しい。そうした視点で研究を進めることは、基礎的な進化生物学の理解につながるとともに、ヒトに最も近縁なチンパンジーを対象としたことで、ヒト自身のゲノム、メタゲノム進化の背景を探る契機となった。また、メタゲノムの確立は後天的要素が大きいものなので、飼育下動物の福祉にも貢献する知見である。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.2016
Author(s)
K. Tsutsui, M. Otoh, K. Sakurai, N. Suzuki-Hashido, T. Hayakawa, T. Misaka, Y. Ishimaru, F. Aureli, A. D. Melin, *S. Kawamura, *H. Imai.
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Journal Title
BMC Evolutionary Biology
Volume: 16
Issue: 1
Pages: 208-208
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Microbiome adaptation and flexibility to the captive environments in lessor slow loris2017
Author(s)
Takashi Hayakawa, Kei Matsushima, Wataru Yano, Yumi Yamanashi, Daisuke Shimizu, Yumiko Terao, Fumihiko Okumura, Mari Hirosawa, Yui Fujimori, Naoki Okabe, Sayaka Tsuchida, Kazunari Ushida
Organizer
The 8th International Symposium on Primatology and Wildlife Science
Related Report
Int'l Joint Research
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