| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Bacteria belonging to actinomycete group present a rich source of novel bioactive compounds. These compounds are often used in medicine, agriculture and other fields. However, most bioactive compounds which respective biosynthetic genes are found in actinomycetal genomes are not produced under laboratory conditions. This research aimed to search for such silent genes and respective compounds in marine actinomycetes and trigger their expression by optimization of cultivation conditions.
As the result, one potentially novel polyketide derivative has been isolated and its candidate biosynthetic gene cluster was found in the genome of the producer. Conditions necessary for compound production activation were analyzed and may be applied in future for cultivation of other actinomycete strains.
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