D-amino acid biological system in eukaryote
| Project/Area Number |
16K18686
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
Ito Tomokazu 名古屋大学, 生命農学研究科, 講師 (90584970)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | D-セリン / D-アスパラギン酸 / D-アミノ酸 / D-セリンデヒドラターゼ / バイオマーカー / セリンラセマーゼ / 腎機能 |
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| Outline of Final Research Achievements |
We analyzed the catalytic and regulatory mechanisms of D-Asp synthetic activity of mammalian serine racemase (SR). Data inidicaed that SR is one of mammalian D-Asp biosynthetic enzymes. In addition, we analyzed urinary D-Ser using our D-, and L-Ser enzymatic assay method. The results obtained here suggested that D-Ser levels could be used as a predictable biomarker of renal function reduction in some situations. In addition, we studied the molecular mechanism of developmental abnormalities of Dsd-deficient Dicsyotelium strains and revealed the involvment of D-Ser in cAMP signaling. We found a novel Dsd substrate D-amino acid in the fruiting body of Bunashimeji mushroom, and identified it as (2R, 3S) 2-amino-3,4-dihydroxybutanoic acid.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Occurrence of the (2R,3S)-Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus.2017
Author(s)
Ito T, Yu Z, Yoshino I, Hirozawa Y, Yamamoto K, Shinoda K, Watanabe A, Hemmi Ｈ, Asada Y, Yoshimura T.
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Journal Title
J Agric Food Chem.
Volume: 65
Issue: 30
Pages: 6131-6139
DOI
Related Report
Peer Reviewed
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[Journal Article] Serine racemase is involved in D-aspartate biosynthesis.2016
Author(s)
Ito, T., Hayashida, M., Kobayashi, S., Muto, N., Hayashi, A., Yoshimura, T., Mori, H.
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Journal Title
J Biochem.
Volume: 160
Issue: 6
Pages: 345-353
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Unusual D-Amino acids in mushroom2017
Author(s)
Tomokazu Ito, Zhuoer Yu, Issei Yoshino, Yurina Hirozawa, Kana Yamamoto, Akira Watanabe, Hisashi Hemmi, Yasuhiko Asada, Tohru Yoshimura
Organizer
International Conference of D-Amino Acid Research（IDAR2017）
Related Report
Int'l Joint Research
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