| Project/Area Number |
16K18694
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Research Collaborator |
MUTO Tatsuro
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | フィブロイン / ガングリオシド / 糖鎖修飾 / バイオマテリアル / 糖鎖 / シルクフィブロイン / 有機合成 / 生理活性 / 有機化学 / 細胞・組織 / 構造・機能材料 |
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| Outline of Final Research Achievements |
We have developed a chemical modification method for introducing highly bioactive gangliosides to silk fibroin protein, which has been used as a matrix material in the field of tissue engineering. As a glycan to modify silk fibroin, the glycan part of echinodermatous ganglioside LLG-3 was chosen due to a high degree of the neurogenic activity and chemically synthesized. The synthetic LLG-3 glycan with a linker bearing an aromatic amine at the terminal was coupled with tyrosine residues in silk fibroin via diazonium coupling reaction, leading to the generation of ganglioside-modified silk fibroin for the first time.
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