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Studies on the effect of food ingredients on prevention and improvement of metabolic disorder with enteral inflammation

Research Project

Project/Area Number 16K18703
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionKyoto University

Principal Investigator

Takahashi Haruya  京都大学, 農学研究科, 助教 (30750369)

Research Collaborator MOHRI Shinsuke  
SAKAI Maiko  
GOTO Tsuyoshi  
KAWADA Teruo  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords食品機能性 / 肥満予防 / 食品分析 / 食品 / 機能性 / 肥満 / 機能性成分 / 植物 / 農学 / 農芸化学 / 食品科学 / 食品機能
Outline of Final Research Achievements

In the modern society, the obesity is recognized as a serious problem. Therefore, the identification of the ingredient derived from the food which is effective for the obese prevention and improvement and the functional analysis of the ingredient are important in contributing to the health promotion of the nation. Tomato is one of the most popular vegetables and is associated with a reduced risk of diabetes. However, the molecular mechanism underlying the effect of tomato on diabetes is unclear. In this study, I focused on anti-inflammatory compounds in tomato.
In this study, we showed that a large number of compounds were estimated as anti-inflammatory compounds. Furthermore, We obtained the in vivo data which suggested that a tomato extract inhibited inflammation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions2018

    • Author(s)
      Mohri Shinsuke、Takahashi Haruya、Sakai Maiko、Takahashi Shingo、Waki Naoko、Aizawa Koichi、Suganuma Hiroyuki、Ara Takeshi、Matsumura Yasuki、Shibata Daisuke、Goto Tsuyoshi、Kawada Teruo
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: e0191203-e0191203

    • DOI

      10.1371/journal.pone.0191203

    • NAID

      120006459972

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rice Koji Extract Enhances Lipid Metabolism through PPARα Activation in Mouse Liver2016

    • Author(s)
      Takahashi H, Chi H-Y, Mohri S, Kamakari K, Nakata K, Ochijo N, Nakata R, Inoue H, Goto T, Kawada T.
    • Journal Title

      J Agric Food Chem.

      Volume: 64 Issue: 46 Pages: 8848-8856

    • DOI

      10.1021/acs.jafc.6b03516

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] トマト成分の新たな健康機能の解明2017

    • Author(s)
      高橋 春弥
    • Organizer
      京都アカデミアフォーラムin丸の内 京大テックフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 肥満・エネルギー代謝不全を惹起する慢性炎症と食品2017

    • Author(s)
      高橋 春弥
    • Organizer
      日本食物繊維学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 麹抽出物の脂質代謝改善作用に関する研究2017

    • Author(s)
      高橋 春弥、Hsin-Yi Chi、毛利 晋輔、鎌苅 浩介、中田 啓司、一條 範好、中田 理恵子、井上 裕康、後藤 剛、河田 照雄
    • Organizer
      日本農芸化学会京都大会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
  • [Presentation] LC-MSを用いたトマト含有抗炎症化合物の広範囲スクリーニングおよび同定化合物における作用機序の解明2017

    • Author(s)
      毛利 晋輔、高橋 春弥、坂井 麻衣子、高橋 慎吾、脇 尚子、相澤 宏一、菅沼 大行、荒 武、柴田 大輔、後藤 剛、河田 照雄
    • Organizer
      日本農芸化学会京都大会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
  • [Presentation] Screening for anti-inflammatory compounds in tomato extract by LC-MS analysis and elucidating the mechanism of their functions2016

    • Author(s)
      Mohri S, Takahashi H, Sakai M, Takahashi S, Waki N, Aizawa K, Suganuma H, Ara T, Shibata D, Goto T and Kawada T
    • Organizer
      2016 KoSFoST International Symposium and Annual Meeting
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2016-08-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] LC-MSを用いたトマト果実中に含まれる抗炎症化合物の探索及び作用機序の解明2016

    • Author(s)
      毛利 晋輔、高橋 春弥、坂井 麻衣子、高橋 慎吾、脇 尚子、荒 武、柴田 大輔、相澤 宏一、菅沼 大行、田村 茂夫、後藤 剛、河田 照雄
    • Organizer
      日本栄養・食糧学会神戸大会
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report
  • [Presentation] 麹中に含まれるPPARα活性化成分の探索及び機能解析2016

    • Author(s)
      高橋 春弥、Hsin-Yi Chi、毛利 晋輔、鎌苅 浩介、中田 啓司、一條 範好、中田 理恵子、井上 裕康, 後藤 剛、河田 照雄
    • Organizer
      日本食品分析学会東京大会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] LC-MSを用いたトマト果実中に含まれる抗炎症化合物の探索及び作用機序の解明2016

    • Author(s)
      毛利 晋輔、高橋 春弥、坂井 麻衣子、高橋 慎吾、脇 尚子、荒 武、柴田 大輔、相澤 宏一、菅沼 大行、田村 茂夫、後藤 剛、河田 照雄
    • Organizer
      日本食品分析学会東京大会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] LC-MSを用いた植物及び動物生体内の分析・機能解析2016

    • Author(s)
      高橋 春弥
    • Organizer
      MSフォーラム大阪
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] LC-MSを用いた植物及び動物生体内の分析・機能解析2016

    • Author(s)
      高橋 春弥
    • Organizer
      MSフォーラム東京
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] LC-MSを用いた抗炎症化合物のスクリーニングおよび作用機序の解析2016

    • Author(s)
      坂井 麻衣子、毛利 晋輔、高橋 春弥、高橋 慎吾、脇 尚子、荒 武、柴田 大輔、相澤 宏一、菅沼 大行、後藤 剛、河田 照雄
    • Organizer
      日本肥満学会東京大会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] Screening for bioactive compounds in tomato extract and elucidating the mechanism of their functions2016

    • Author(s)
      Takahashi H, Mohri S, Sakai M, Waki N, Takahashi S, Suganuma H, Goto T, Kawada T and Shibata D
    • Organizer
      Wageningen University and Kyoto University International Exchange Program. Seminar on Food Science by Young Researchers
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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