A novel mechanism of regulation of lipid metabolism by protein malnutrition-induced Fgf21
| Project/Area Number |
16K18706
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | FGF21 / 低タンパク質食 / タンパク質低栄養 / 低タンパク質 / 肝臓脂肪 / アミノ酸欠乏 |
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| Outline of Final Research Achievements |
Protein malnutrition promotes hepatic steatosis. Meanwhile, protein malnutrition up-regulates Fgf21 expression, which suppresses hepatic steatosis. This study was undertaken to elucidate the mechanism of the protective effect of Fgf21 against hepatic steatosis under protein malnutrition conditions. We showed that Fgf21 is required for up-regulation of Ucp-1 in adipose tissues under protein malnutrition conditions. However, increased Ucp-1 is not required for the protective effect of Fgf21 against hepatic steatosis. Moreover, the protective effect of Fgf21 against hepatic steatosis is not mediated by reduced liver TAG secretion since Fgf21 does not influence liver TAG secretion under protein malnutrition conditions.
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Report
(3 results)
Research Products
(36 results)
