| Project/Area Number |
16K18786
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ヒストン脱アセチル化酵素 / 酪酸 / 栄養代謝 / 性ホルモン産生 / 性ホルモン / 栄養・飼養 |
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| Outline of Final Research Achievements |
It is the ultimate target of us to improve reproductive disorders of dairy cow by reduction of hepatic dysfunction. For that purpose, we studied the function of butyric acid. In bovine ovarian granulosa cells, the gene expression involved in sex hormone production was maintained when granulosa cells were supplemented with butyric acid (0.25 mM) at the same level as bovine blood levels.Therefore, in order to induce the HDAC inhibitory effect of butyric acid, it may be necessary to adjust the concentration of blood butyric acid within a certain range. Meanwhile, when butyric acid at a higher level than 1.0 mM was added, expression of genes involved in sex hormone production was lowered.This suggests that excessive increase in bovine blood butyrate concentration cause a decrease in reproductive performance.
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