Spatial-Temporal profile of ultrasound-mediated cisplatin delivery
| Project/Area Number |
16K18799
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SASAKI Noboru 北海道大学, 獣医学研究科, 助教 (00754532)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 超音波治療 / ドラッグデリバリー / 細胞内薬剤濃度 / 非侵襲 / 膀胱癌 / 細胞内濃度 / 抗がん剤 / 3次元培養 |
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| Outline of Final Research Achievements |
Ultrasound-triggered microbubble cavitation is a promising tool for drug and gene delivery in cancer therapy. We evaluated the temporal and spatial profile of cisplatin delivery by ultrasound-triggered microbubble cavitation. We used a bladder cancer mimicking 3D culture model for this study. Single treatment of ultrasound-triggered microbubble cavitation increased an intracellular concentration of cisplatin at the thickness of 100 μm. The duration of enhanced delivery was 1 hr. Based on the distance and duration of delivery, we further tested the feasibility of repetition of the treatment. Triple treatment increased the effective distance by 2-fold. Our results clearly showed spatial and temporal profile of delivery by ultrasound-triggered microbubble cavitation in a tumor-mimicking structure. The results of this study suggest that ultrasound-triggered microbubble cavitation can be repeatable and is promising for cancer treatment.
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Report
(3 results)
Research Products
(8 results)
