| Project/Area Number |
16K18808
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂肪由来間葉系幹細胞 / 肝細胞癌 / 肝星細胞 / 犬 / 腫瘍微小環境 / 脂肪由来幹細胞 / 内科 |
|---|
| Outline of Final Research Achievements |
It was revealed that the activation and differentiation of hepatic stellate cells were facilitated by the canine adipose tissue-derived mesenchymal stem cells. These alterations could be induced by the soluble factor secreted from adipose tissue-derived mesenchymal stem cells. The differentiation and invasion abilities of canine hepatic carcinoma cells also were up-regulated by soluble factor secreted from adipose tissue-derived mesenchymal stem cells. Moreover, mRNA expression levels of factors related to the tumor development were significantly higher in canine hepatic carcinoma cells co-cultured with soluble factor secreted from adipose tissue-derived mesenchymal stem cells.
These findings suggest that soluble factors from adipose tissue-derived mesenchymal stem cells promote the proliferation and invasion of canine hepatocellular carcinoma cells including tumor microenviroment.
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