Identification and analysis of central action of the pheromone that modulates reproductive physiology in mice
| Project/Area Number |
16K18811
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Murata Ken 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員 (30749643)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | フェロモン / 生殖 / キスペプチン / GnRH / 神経科学 |
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| Outline of Final Research Achievements |
The aim of this research is to record the neural activity of central regulator of reproduction to reveal the central response to male pheromone exposure and identify the pheromone molecule based on the response in mice. By using optogenetic technology, we established a system to record neural activity of neurons expressing specific genes in specific brain area. It was shown that exposure to male mouse urine containing pheromone activated the central regulator of reproduction. Furthermore, relatively low molecular weight hydrophilic compounds in male mouse urine were suggested to have pheromone activity.
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Report
(3 results)
Research Products
(3 results)
