The mechanism of Epigenetics control in Japanese Black beef

• Project/Area Number: 16K18814
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: Kyushu University
• Principal Investigator: Takahashi Hideyuki 九州大学, 農学研究院, 助教 (60549872)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 黒毛和牛 / 強化哺乳 / 畜産学

Outline of Final Research Achievements

In this study, we focused on insulin-like growth factor-1 (IGF-1) and glucose / lipid metabolism related factors involved in myogenesis and lipid metabolism to establish early fattening technology, and these factors are epigenetic The purpose of this study was to obtain the basic knowledge about "Does the trait acquired by the calf in the calf period pass on to the next generation" as well as to determine whether it receives the control mechanism of tic control. Blood glucose levels of calves born to cows fed a large amount of milk replacer decreased in both the feeding and growing periods. From this, it is suggested that by supplying a milk replacer to a cow candidate cow, production of a calf with high glucose uptake becomes possible, and production of an excellent calf without nutrient absorption ability is possible.

Academic Significance and Societal Importance of the Research Achievements

早期肥育技術は肥育期間を6か月短縮し、飼料コストを下げ収益を得ることである。したがって、早期肥育技術確立するためには、成長を早めることが求められる。その方法として代用乳を多給する飼養管理が広まりつつあるが、代用乳のコストが加算するため、早期肥育のメリットが生かせない。本研究成果は、母牛候補牛に代用乳を多給することにより、仔牛生産のコストは増やさずに早期肥育が可能となる技術となる。

Research Products

• [Journal Article] Physiological Responses of Japanese Black Calves to Supplementation with Sodium Butyrate in Milk Replacer (2018)
  • Author(s): Toru Asahina, Kosuke Nakagiri, Yuji Shiotsuka, Tetsuji Etoh, Ryoichi Fujino, Nonomi Suzuki, Christopher D. McMahon, Hideyuki Takahashi
  • Journal Title: Food & Nutrition Journal Volume: 4 Issue: 4 Pages: 1-4
  • DOI: 10.29011/2575-7091.100083
  • Peer Reviewed / Open Access
• [Journal Article] Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats (2017)
  • Author(s): Takahashi Hideyuki、Suzuki Yutaka、Mohamed Junaith S.、Gotoh Takafumi、Pereira Suzette L.、Alway Stephen E.
  • Journal Title: Experimental Gerontology Volume: 92 Pages: 56-66
  • DOI: 10.1016/j.exger.2017.02.075
  • Peer Reviewed
• [Journal Article] Higher intake of milk-replacer pre-weaning enhances post-weaning insulin-like growth factor 1 levels in Japanese Black cattle (2016)
  • Author(s): H Takahashi, A Matsubara, A Saito, O Phomvisith, A Shiga, HT Mai, T Sugino, CD McMahon, T Etoh, Y Shiotsuka, R Fujino, M Furuse, T Gotoh
  • Journal Title: Journal of Veterinary Science & Technology Volume: 8 Issue: 01 Pages: 409-409
  • DOI: 10.4172/2157-7579.1000409
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of a high milk intake during the pre-weaning period on nutrient metabolism and growth rate in Japanese Black cattle (2016)
  • Author(s): A Matsubara, H Takahashi, A Saito, A Nomura, K Sithyphone, CD McMahon, R Fujino, Y Shiotsuka, T Etoh, M Furuse, T Gotoh
  • Journal Title: Animal Science Journal Volume: 87 Issue: 9 Pages: 1130-1136
  • DOI: 10.1111/asj.12547
  • Peer Reviewed / Int'l Joint Research