Elucidation of maintenance mechanism of mammalian oocyte dormancy
| Project/Area Number |
16K18815
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
Nakajima Yuki 九州大学, 稲盛フロンティア研究センター, 特任助教 (50743126)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 卵母細胞 / 休眠 / クロマチン / クロマチン形態 / 発生・分化 / 繁殖 / 発生工学 / エピジェネティクス |
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| Outline of Final Research Achievements |
Mammalian oocyte develops as a follicle that is enclosed with somatic cells and is ovulated after maturation. However, more than 99% of follicles are arrested during folliculogenesis and its mechanism is unclear. In the present study, therefore, we investigated the mechanism of oocyte dormancy maintenance and that of oocyte activation. We first developed a method to isolate follicles which does not require enzymatic treatment of ovaries. Then, with the use of the developed method, we revealed that nuclei of oocytes in dormant primordial follicles are dominated by euchromatin structure, suggesting an association between dormancy of oocytes and their chromatin structure.
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Report
(3 results)
Research Products
(2 results)
