| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
In dogs and human, mutations and reduction expression level of BRCA2, one of tumor suppressor gene, are related to mammary tumor development. We had found a novel DNA region that suppresses BRCA2 promoter activity in preliminary study. In this study, we limited the region which include the suppressor activity to 50 bp length. A several proteins were interacted with this DNA sequence in vitro and one of them showed the suppressor effect on BRCA2 promoter activity.
|
