Analysis of neural crest-derived cells in pituitary development
| Project/Area Number |
16K18818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Jikei University School of Medicine (2017-2018)
Meiji University (2016) |
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Principal Investigator |
YOSHIDA SAISHU 東京慈恵会医科大学, 医学部, 助教 (40772744)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 下垂体 / 神経堤細胞 / 幹細胞 / 発生 / 分化 / S100b / 幹細胞ニッチ / 腫瘍化 |
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| Outline of Final Research Achievements |
The anterior lobe of the pituitary gland is a key endocrine organ which is believed to derive from the ectoderm. In this study, we attempt to clarify the role of neural crest cells (NCCs) in pituitary development using P0-Cre/EGFP reporter mice. Fate tracing of NCCs demonstrated that NCCs differentiate into all types of pituitary hormone-producing cells as well as pituitary stem/progeny cells. These results showed that NCCs contribute to pituitary organogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、これまで外胚葉由来と考えられてきた下垂体前葉に関して、神経堤細胞がその起源の一部を構成することを見出した。同一のホルモン産生細胞種の中に、異なる起源の細胞が存在することが、下垂体の機能維持や腫瘍化に対して、どのような意義を有するのかが今後の重要な課題である。こうした知見は、脳腫瘍の約17%を占める下垂体腫瘍の発生機序に対する新知見に繋がると期待される。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.2019
Author(s)
Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, Yoshida K.
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Journal Title
Cancer Lett
Volume: 451
Pages: 100-109
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differentiation capacities of PS-clusters, adult pituitary stem/progenitor cell clusters located in the parenchymal-niche, of the rat anterior lobe2018
Author(s)
S. Yoshida, N. Nishimura, H. Yurino, M. Kobayashi, K. Horiguchi, K. Yano, SI. Hashimoto, T. Kato, Y. Kato
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Journal Title
PLOS ONE
Volume: 13
Issue: 4
Pages: e0196029-e0196029
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Construction and expression of vectors encoding biologically active rodent gonadotropins2017
Author(s)
A. Ohta, Y. Tsunoda, Y. Tamura, K. Iino, N. Nishimura, H. Nishihara, H. Takanashi, S. Yoshida, T. Kato, Y. Kato.
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Journal Title
Journal of Reproduction and Development
Volume: 63
Issue: 6
Pages: 605-609
DOI
NAID
ISSN
0916-8818, 1348-4400
Related Report
Peer Reviewed / Open Access
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