| Project/Area Number |
16K18834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Chiba University |
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Principal Investigator |
Shimada Takashi 千葉大学, 大学院園芸学研究科, 助教 (10713828)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ホスファチジルイノシトールリン酸 / シロイヌナズナ / 炭疽病菌 / 細胞動態 / PI(4,5)P2 / PIP5キナーゼ / アクチン / PtdIns(4,5)P2 / 病理学 |
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| Outline of Final Research Achievements |
Phosphatidylinositides are essential for cellular dynamics of plants. We found that one of Phosphatidylinositides, PI(4,5)P2 accumulated in extra-invasive-hyphal membrane during Colletotrichum infection. Overexpressing PIP5K (an enzyme for PI[4,5]P2 production) caused higher susceptibility to Colletotrichum than wild type. These results suggest that Colletotrichum induces the PI(4,5)P2 production in plants for its infection.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により，炭疽病菌感染のためには，植物細胞内で，微量脂質であるPI(4,5)P2の集積が重要であることが明らかになった．PI(4,5)P2は植物の生存に必須の脂質であるため，炭疽病菌はそのシステムを効率よく乗っ取り，感染を成立させていることが示唆された．炭疽病菌の防除ためには，PI(4,5)P2の量を適切に保つ必要があることが本研究より示された．
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