Development of catalytic cyclization and sequential cross-coupling reaction by utilizing the feature of chemical elements
| Project/Area Number |
16K18841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Saito Tatsuo 東京大学, 大学院薬学系研究科(薬学部), 助教 (40612065)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ポリエーテル / 環化反応 / マイトトキシン / 天然物合成 / DFT計算 / 機能性分子 / クロスカップリング / 連続反応 |
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| Outline of Final Research Achievements |
We have developed an efficient regioselective formation of six-/seven-membered cyclic ethers based on gold-catalyzed intramolecular hydroalkoxylation. We demonstrated sequential cyclization/cross-coupling reactions to afford polycyclic ethers. Furthermore, stereoselective synthesis of the ent-ZA′B′C′D′-ring system of maitotoxin has been accomplished through a convergent strategy utilizing Suzuki－Miyaura cross coupling reaction.
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Report
(3 results)
Research Products
(7 results)
