Development of helicenyl phosphines and their application in catalytic asymmetric reactions
| Project/Area Number |
16K18846
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
Usui Kazuteru 九州大学, 薬学研究院, 助教 (80553304)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 不斉合成 / キラリティー / ヘリセン / らせん / ホスフィン配位子 / 不斉触媒反応 / 有機化学 / 螺旋 |
|---|
| Outline of Final Research Achievements |
A series of novel optically active [5]helicene-derived phosphine ligands (L1, with a 7,8-dihydro[5]helicene core structure, and L2, with a fully aromatic [5]helicene core structure) were synthesized. The prepared ligands, especially L1, were found to be highly effective in asymmetric allylation of 1,3-diphenylallyl acetate with indoles (up to 99% ee) and etherification with alcohols (up to 96% ee). In asymmetric Suzuki-Miyaura coupling reaction, L2 shown excellent enantioselectivities (up to 99% ee).
|
Report
(3 results)
Research Products
(43 results)
