Development of domino doublespiro cyclization

Research Project

Project/Area Number	16K18853
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Chemical pharmacy
Research Institution	Hoshi University
Principal Investigator	Yokoe Hiromasa 星薬科大学, 薬学部, 助教 (10613622)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	ドミノ反応 / スピロ環化 / 薬剤耐性克服効果 / ジアステレオ選択的 / 全合成 / 多剤耐性克服効果 / 薬学 / 有機化学 / 合成化学
Outline of Final Research Achievements	We have developed a method for the synthesis of doublespirocycles in high yield and high diastereoselective manner. In addition, we have also established a simple and rapid method for the synthesis of the cyclization precursor. The reaction we developed here was applied to the synthetic study on the grandilodine C with drug-resistant reversing effect.

Report

(3 results)