| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We have developed the new metal-free coupling method of nucleobase derivatives such as purines toward nucleophiles (i.e. electron-rich arenes or amines), and facile synthesis of uracil-iodonium(III) salts as new attractive synthetic modules of these nucleobases. We have investigated in detail the optimized conditions for generating highly strained heterocyclic alkyne species from uracil-iodonium(III) salts with basic activation, which have led to development of the new vicinal functionalization of the uracil ring in a single synthetic operation.
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