| Project/Area Number |
16K18855
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Research Collaborator |
GODA Mitsuhiro
KOBAYASHI Naoki
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | フッ素 / ジフルオロ-β-ラクタム / 人工ペプチド / β-アミノ酸 / 加水分解 / 酵素 / ペプチド合成 / 含フッ素化合物 / ペプチド / 有機化学 |
|---|
| Outline of Final Research Achievements |
I studied a synthesis of artificial peptide including fluorinated β-amino acid as a non-proteinogenic amino acid and focused on the utility of fluorinated peptides as a functionalized peptide using the property of fluorine substituents. The construction of the desired peptide was realized by the ring-opening reaction of a highly electrophilic difluoro-β-lactam with amino acid without a condensation reagent in trifluoroethanol. Unfortunately, the evaluation of functionality for sterically interaction of the fluorinated peptide could not be achieved. However, the obtaining peptides showed the tolerance for enzymatic hydrolysis.
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