The mechanism of novel LPA3-mediated activation of vagal afferent nerve
| Project/Area Number |
16K18870
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
Kano Kuniyuki 東北大学, 薬学研究科, 助教 (50636404)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リゾホスファチジン酸 / 迷走神経 / 心筋梗塞 / ドコサヘキサエン酸 / リゾリン脂質 |
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| Outline of Final Research Achievements |
Imaging MS and LC-MS/MS analysis revealed that lysophosphatidic acid (LPA) containing docosahexaenoic acid (DHA (22:6)) was selectively elevated in the ischemic heart. Administration of autotaxin (ATX) inhibitor did not affect the increase of DHA-LPA, suggesting that DHA-LPA was produced in ATX-independent manner.
LPA3 agonist induced a transient apnea and a prolonged hypopnea, which is resulted from activation of vagus nerve. We also found novel pharmacological action of LPA3 agonist independent on vagus nerve.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Different Origins of Lysophospholipid Mediators between Coronary and Peripheral Arteries in Acute Coronary Syndrome.2017
Author(s)
Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
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Journal Title
J. Lipid Res.
Volume: 58
Issue: 2
Pages: 433-442
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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