| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Alzheimer disease (AD) is a neurodegenerative disease characterized by the deposition of senile plaques, which are composed of amyloid β peptide (Aβ). As rate of Aβ clearance from the brain is impaired in sporadic AD cases, understanding the molecular mechanism of Aβ clearance is important. In this study, we have performed the genome-wide screening for Aβ uptake ability using CRISPR/Cas9 system, and established the validation method in Cas9 knockin mouse. Using these strategies, we have identified several genes and cell function involving Aβ uptake. Additionally, our data indicate that one of the known AD risk genes may exert effect by Aβ uptake pathway.
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