| Project/Area Number |
16K18872
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HATTORI KAZUKI 東京大学, 大学院薬学系研究科(薬学部), 助教 (40708575)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ASK1 / 褐色脂肪 / Ucp1 / フェロトーシス / 低温ストレス / p38MAPK / ASKファミリー / 白色脂肪 / MAPK |
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| Outline of Final Research Achievements |
It is inevitable to discover molecular characteristics of one single molecule if you think it as a therapeutic target for some diseases. Our main target, ASK1, is an oxidative stress-responsive kinase, which mainly regulates cell death process. We hereby revealed the two novel functions of ASK1: (1) ASK1 regulates a specific subset of gene expression including thermo-producing protein, Ucp1, and contributes to thermogenesis in brown adipocytes. (2) Prolonged cold stress actives ASK1-p38 axis, which induces a type of cell death, ferroptosis. These findings provided novel insights to develop therapeutic methods targeting to ASK1, especially in the field of metabolic diseases and tissue preservation.
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