| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This study suggested that B-cell receptor associated protein 31 (BAP310 regulates both endoplasmic reticulum stress induced cell death and autophagy that contributes to cell survival. The suppression of BAP31 expression in cancer cells indicated that these cells are able to proliferate under severe environmental conditions, such as hypoxia and stavation, and have high ability of metastasis in vivo. Thus, there is a pssibility of BAP31 as a novel tummor suppressive factors that determine cell death and survival.
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