| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Uric acid has been reported to be neuroprotective and inhibits neuronal death in Parkinson’s disease model mice. In this study, we established double mutant mouse of novel Alzheimer’s disease model mice（AppNL-G-F/NL-G-F） and knockout mice of uricase, which metabolize uric acid to allantoin. We performed immunohistochemistry of amyloid β and Y-maze test using 7-8 months old mice. However, we did not observed inhibition of accumulation of amyloid βand inhibition of reduced cognitive function.
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