| Project/Area Number |
16K18883
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
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Principal Investigator |
Okada-Tsuchioka Mami 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 研究員(移行) (30517280)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | シナプス新生 / うつ病 / アストロサイト / thrombospondin-1 / 電気けいれん療法 |
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| Outline of Final Research Achievements |
I have focused on synaptogenesis-related factor, thrombospondin-1 (TSP-1), as a novel target molecule of refractory depression. The aim of this study was to clarify how TSP-1 contributes to the pathology of depression and the action of electroconvulsive therapy (ECT). Serum TSP-1 in patients with refractory depression showed a significant decrease specific to female patients but did not change before and after ECT. These results suggest that TSP-1 in serum is possible to be a gender-dependent trait marker.
As basic research, synaptogenesis-related gene expression was investigated in the hippocampus of the male chronically corticosterone-administered depression model, but no significant change was observed. It seems necessary to investigate focusing on gender difference in the future.
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