The role of spinal dorsal horn astrocytes in sensory information processing
| Project/Area Number |
16K18885
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
Kohro Yuta 九州大学, 薬学研究院, 助教 (30723861)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脊髄後角 / アストロサイト / 感覚情報伝達 / 亜集団 / 痛み |
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| Outline of Final Research Achievements |
Astrocytes in the spinal dorsal horn (SDH) have an important role in the maintenance of neuropathic pain after peripheral nerve injury. However, under normal condition, little is known about how much SDH astrocytes actively influence sensory information processing in vivo. In this study, we established the selective activation of SDH astrocytes in vivo and clarified their role of modulating innocuous mechanical information processing. Furthermore, we found that SDH astrocytes sensitized light mechanical information after peripheral noxious stimuli.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、これまで未解明であった脊髄後角アストロサイトの感覚情報伝達における役割の解明に成功した。さらに成体脊髄後角アストロサイトの亜集団を世界で初めて同定し、同集団が感覚情報伝達の変調に中心的役割を果たすことを見出した。今後、慢性疼痛を含む病態時における役割について検討を行うことで、同集団をターゲットとした治療薬の開発へと繋がる可能性がある。
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-LikeSensory and Emotional Behaviors after Nerve Injury in Rats.2018
Author(s)
Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K,Matsushita K, Tozaki-Saitoh H, Fukazawa Y, Inoue K, Yawo H, Furue H, Tsuda M
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Journal Title
eNeuro
Volume: 5(1)
Issue: 1
Pages: 0450-17
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.2016
Author(s)
S. Koyanagi, N. Kusunose, M. Taniguchi, T. Akamine, Y. Kanado, Y. Ozono, T. Masuda, Y. Kohro, N. Matsunaga, M. Tsuda, M. Salter, K. Inoue, and S. Ohdo.
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Journal Title
Nat. Commun.
Volume: 7
Issue: 1
Pages: 13102-13102
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain.2016
Author(s)
Masuda T, Ozono Y, Mikuriya S, Kohro Y, Tozaki-Saitoh H, Iwatsuki K, Uneyama H, Ichikawa R, Salter MW, Tsuda M, Inoue K
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Journal Title
Nat Commun.
Volume: 7
Issue: 1
Pages: 12529-12529
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] 細胞2016
Author(s)
増田隆博，津田誠，齊藤秀俊，高露雄太，井上和秀
Publisher
ニューサイエンス社
Related Report
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