• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The treatment of steroid-induced depression

Research Project

Project/Area Number 16K18888
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pharmacology in pharmacy
Research InstitutionFukuoka University

Principal Investigator

TERADA KAZUKI  福岡大学, 薬学部, 助教 (00724197)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsステロイド / 神経成長因子 / SSRI / sigma-1受容体 / Sigma-1受容体 / Sigma-2受容体 / うつ病 / シグマ受容体 / 神経突起伸展 / 副腎皮質ステロイド / システム薬理学 / ステロイド誘起性うつ病 / 薬理学
Outline of Final Research Achievements

Glucocorticoids, also called steroids, are important mediators of the stress response and commonly used as drugs for various diseases. Previous studies have suggested the possibility of patients with depression undergoing long-term treatment with synthetic glucocorticoids. However, the methods used to assess such a steroid-induced depression and the associated pathogenesis mechanism have not been established.
In the present study, we showed that fluvoxamine suppressed via the sigma-1 receptor on neurite outgrowth inhibition induced by steroid in PC12 cells. Additionally, fluvoxamine improved steroid-induced depression-like behaviour of the mice in the forced swimming test. Therefore, sigma-1 receptor may be an effective target for steroid-induced depression.

Academic Significance and Societal Importance of the Research Achievements

副腎皮質ステロイド剤はうつ症状などの副作用を誘起することが知られているが、この副作用に対する対処はステロイド剤の用量調節や中止など限定的である。また、抗うつ薬によってはその症状を悪化させるものもあり、発症機序や治療法に関わるる情報が強く望まれる。本研究では、ステロイド剤によって誘起される影響に対し現在抗うつ薬として用いられる薬剤の中でsigma-1受容体に親和性を有する薬剤が有効であることを見出した。これらの結果は、ステロイド剤使用による精神症状の副作用が発現した際の治療法に大きな情報源となることが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells2019

    • Author(s)
      Matsushima Y, Terada K, Takata J, Karube Y, Kamei C, Sugimoto Y.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 83 Issue: 4 Pages: 659

    • DOI

      10.1080/09168451.2018.1553607

    • URL

      https://pure.teikyo.jp/en/publications/6b1a160f-e0b8-45a1-a117-3648982d670e

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor2019

    • Author(s)
      Matsushima Y, Terada K, Kamei C, Sugimoto Y.
    • Journal Title

      Eur J Pharmacol

      Volume: 853 Pages: 129

    • DOI

      10.1016/j.ejphar.2019.03.032

    • URL

      https://pure.teikyo.jp/en/publications/9102ab78-4f67-4d88-9148-dd2906c52bac

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sigma-2 receptor as a potential therapeutic target for treating central nervous system disorders2019

    • Author(s)
      Terada K, Migita K, Matsushima Y, Kamei C
    • Journal Title

      Neural Regen Res

      Volume: 14 Issue: 11 Pages: 1893

    • DOI

      10.4103/1673-5374.259609

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors2018

    • Author(s)
      Terada K, Migita K, Matsushima Y, Sugimoto Y, Kamei C, Matsumoto T, Mori M, Matsunaga K, Takata J, Karube Y
    • Journal Title

      PLoS One

      Volume: 13 Issue: 12 Pages: 1-16

    • DOI

      10.1371/journal.pone.0209250

    • URL

      https://pure.teikyo.jp/en/publications/84c8461d-1014-4107-80a5-2f4c89d2bb40

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The kampo medicine yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells2017

    • Author(s)
      Terada K, Matsyshima Y, Matsunaga K, Takata J, Karube Y, Ishige A, Chiba K.
    • Journal Title

      Bosn J Basic Med Sci.

      Volume: 18 Issue: 3 Pages: 224

    • DOI

      10.17305/bjbms.2017.2248

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 副腎皮質ステロイド剤によるマウス行動と神経成長因子の変化2020

    • Author(s)
      西原奈都美、土岐衣梨奈、寺田一樹、後藤将太朗、松永和久、山川博文、渡瀬大輔、瀬戸口修一、古賀允久、髙田二郎、加留部善晴
    • Organizer
      日本薬学会 第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fluvoxamine recovered the nerve growth factor-induced neurite outgrowth inhibited by dexamethasone2019

    • Author(s)
      Toki E, Terada K, Goto S, Yamakawa H, Matsunaga K, Watase D, Setoguchi S, Takata J, Karube Y.
    • Organizer
      32nd European College of Neuropsychopharmacology congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経様細胞PC12におけるNGF依存性神経突起伸展作用に対するリバスチグミンの増強機構2019

    • Author(s)
      寺田一樹、松嶋ゆかり、渡瀬大輔、山川博文、松永和久、瀬戸口修一、後藤将太朗、右田啓介、髙田二郎、加留部善晴
    • Organizer
      第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] セルトラリンのPC12細胞におけるNGF誘発性神経突起伸展に対する抑制作用について2018

    • Author(s)
      松嶋ゆかり、寺田一樹、亀井千晃、杉本由美
    • Organizer
      第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] PC12細胞におけるステロイドの神経突起伸展抑制作用に対するフルボキサミンの効果2017

    • Author(s)
      寺田 一樹
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎県 長崎パブリックホール
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 神経様細胞PC12におけるNGF依存性神経突起伸展作用に対するリバスチグミンの増強効果2017

    • Author(s)
      寺田一樹、須賀妃奈子、山川博文、松永和久、加留部善晴、千葉康司、髙田二郎
    • Organizer
      第39回日本生物学的精神医学・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi