| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Our previous studies have implied the possibility that epigenetic modification-induced abnormal regulation of neuronal excitability in the dorsal raphe nucleus may cause environmental factor-induced psychiatric disorders. In this study, we showed that alterations of the expression and epigenetic modification in GABA/5-HTergic neuron-related genes in the dorsal raphe nucleus of social defeat stress model mice. Furthermore, we also found the alterations of the prefrontal 5-HTergic function in the social defeat stress model mice. These transcriptional and neurochemical alterations may be involved in the environmental factor-induced psychological dysfunctions.
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