The involvement of epigenetic regulation of GABAB1a in the pathophygiologies
Project/Area Number |
16K18891
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
|
Research Institution | Setsunan University |
Principal Investigator |
ARAKI Ryota 摂南大学, 薬学部, 助教 (90710682)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | エピジェネティクス / セロトニン / GABA / 環境要因 / DNAメチル化 / Tph2 / 社会的敗北ストレス / 背側縫線核 / Egr-1 / 環境因子 |
Outline of Final Research Achievements |
Our previous studies have implied the possibility that epigenetic modification-induced abnormal regulation of neuronal excitability in the dorsal raphe nucleus may cause environmental factor-induced psychiatric disorders. In this study, we showed that alterations of the expression and epigenetic modification in GABA/5-HTergic neuron-related genes in the dorsal raphe nucleus of social defeat stress model mice. Furthermore, we also found the alterations of the prefrontal 5-HTergic function in the social defeat stress model mice. These transcriptional and neurochemical alterations may be involved in the environmental factor-induced psychological dysfunctions.
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Report
(3 results)
Research Products
(3 results)