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Basic research for seeds search and drug discovery of novel renal cancer therapeutic medications based on proteomics

Research Project

Project/Area Number 16K18892
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pharmacology in pharmacy
Research InstitutionHimeji Dokkyo University

Principal Investigator

Yamamoto Yasuhiro  姫路獨協大学, 薬学部, 准教授 (70533850)

Research Collaborator Koma Hiromi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腎臓癌 / プロテオーム解析 / プロテオミクス / 薬理学 / 癌 / プロテオーム
Outline of Final Research Achievements

Renal cell carcinoma (RCC) is chemoresistant cancer. In this study, we explored the candidates of novel therapeutic medications for RCC. The 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is an endogenous anti-cancerous agent. Treatment with low concentrations at which cell death does not occur, of 15d-PGJ2 decreased the migration of Caki-2 cells. The von Hippel-Lindau (VHL) gene is closely associated with the onset of kidney cancer. 15d-PGJ2 enhanced the effect of anti-cancer agents independently of VHL status in renal cell carcinomas.

Academic Significance and Societal Importance of the Research Achievements

細胞遊走は、悪性腫瘍が原発巣から転移する際に起こる現象である。本研究の検討によって、15d-PGJ2は腎臓癌細胞に対して、細胞死を起こさない低濃度においても、癌細胞の遊走を抑制することが明らかとなった。内因性物質である15d-PGJ2の低濃度適用は、従来の抗がん剤治療に多くみられた副作用である正常細胞に対する細胞毒性を起こすことがないため、危険性の少ない転移治療に応用できることが期待される。また、15d-PGJ2を用いた治療は、VHL遺伝子変異の有無によらずに、抗がん剤の効果を増強することができるため、より多くの腎臓癌症例に応用できる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 15-deoxy-Δ12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas.2019

    • Author(s)
      Koma H, Yamamoto Y, Fujita T, Yagami T.
    • Journal Title

      Biochem Biophys Rep.

      Volume: in press Pages: 100608-100608

    • DOI

      10.1016/j.bbrep.2019.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases.2018

    • Author(s)
      Yagami T, Yamamoto Y, Koma H
    • Journal Title

      Mol Neurobiol.

      Volume: - Issue: 5 Pages: 3090-3112

    • DOI

      10.1007/s12035-018-1277-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological and pathological roles of 15-deoxy -Δ12,14-prostaglandin J2 in the central nervous system and neurological diseases2018

    • Author(s)
      Yagami T, Yamamoto Y, Koma H
    • Journal Title

      Mol Neurobiol

      Volume: 55(3) Issue: 3 Pages: 2227-2248

    • DOI

      10.1007/s12035-017-0435-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-heat Shock 70 kDa Protein Antibody Induced Neuronal Cell Death2017

    • Author(s)
      Yamamoto Y, Koma H, Nishii S, Yagami T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 4 Pages: 402-412

    • DOI

      10.1248/bpb.b16-00641

    • NAID

      130005530110

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 15-deoxy-Δ12,14-prostaglandin J2 in neurodegenerative diseases and cancers2017

    • Author(s)
      Yagami T, Yamamoto Y, Koma H.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 6 Pages: 9007-8

    • DOI

      10.18632/oncotarget.14701

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic effects of 15-deoxy Δ12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma2017

    • Author(s)
      Yasuhiro Yamamoto, Takehiro Yamamoto, Hiromi Koma, Ayaka Nishii, Tatsurou Yagami
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: Volume 9, March 2017 Pages: 61-66

    • DOI

      10.1016/j.bbrep.2016.11.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 抗神経特異的エノラーゼ抗体による神経細胞死はカスパーゼ3不活性化とカスパーゼ1活性化を伴う2019

    • Author(s)
      矢上達郎、山本泰弘、高馬宏美
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎臓癌細胞膜における15デオキシ-デルタ12 14-プロスタグランジンJ2の新規標的タンパク質2019

    • Author(s)
      山本泰弘、高馬宏美、矢上達郎
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 15デオキシ-デルタ12 14-プロスタグランジンJ2は腎細胞癌においてVHLとは独立して抗腫瘍効果を発揮する2019

    • Author(s)
      高馬宏美、山本泰弘、矢上達郎
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 形質膜に局在する電位依存性陰イオンチャンネルは15-deoxy-Δ12, 14-prostaglandin J2膜標的タンパク質の一つである2019

    • Author(s)
      矢上達郎、山本泰弘、高馬宏美
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A plausible involvement of plasmalemmal voltage-dependent anion channel in the neurotoxicity of 15-deoxy-Δ 12;14-prostaglandin J22018

    • Author(s)
      Yamamoto Y, Koma H, Yagami T
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synergistic effects of 15-deoxy-Δ12,14-prostaglandin J2 and anticancer agents on renal cell carcinomas2018

    • Author(s)
      Fujita T, Asanoma Y, Shirai W, Hashimoto E, Echigo T, Yoneda Y, Kumagai H, Yamamoto Y, Koma H, Yagami T
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 15-デオキシ-Δ12, 14-プロスタグランジンJ2とトポイソメラーゼ阻害剤との併用による腎臓癌細胞遊走抑制作用の解析2018

    • Author(s)
      米田有里、山本泰弘、高馬宏美、矢上達郎
    • Organizer
      第68回 日本薬学会 近畿支部総会・大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] VDAC 阻害剤は15-deoxy-△12,14-prostaglandin J2の神経細胞毒性を亢進する2018

    • Author(s)
      熊谷宏昭、山本泰弘、高馬宏美、矢上達郎
    • Organizer
      第68回 日本薬学会 近畿支部総会・大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 15-デオキシ-デルタ12, 14-プロスタグランジンJ2はfocal adhesion kinaseの不活性化によって腎臓癌細胞の遊走を抑制する2018

    • Author(s)
      山本泰弘、高馬宏美、矢上達郎
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 抗14-3-3δ/ξ抗体はカスパーゼ3を不活性化し、ユビキチン化蛋白質の蓄積を抑制し、神経細胞死を誘導する2018

    • Author(s)
      矢上達郎、山本泰弘、高馬宏美
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] The mechanism of 15-Deoxy-Δ-12, 14-prostaglandin J2 of the cell migration on renal cell carcinoma2017

    • Author(s)
      Yasuhiro Yamamoto, Hiromi Koma, Ayaka Nishii, Tatsurou Yagami
    • Organizer
      The 137th Annual Meeting of Japanese Pharmaceutical Society
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Heat shock protein 70抗体の神経細胞死誘導メカニズムの解析2017

    • Author(s)
      山本泰弘、高馬宏美、矢上達郎
    • Organizer
      第67回日本薬学会近畿支部総会・大会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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