| Project/Area Number |
16K18900
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 天然物 / 脂質代謝 / 動脈硬化 / 脂肪肝 / ケミカルバイオロジー / 阻害剤 / 薬学 / 脂質異常症 / 微生物 |
|---|
| Outline of Final Research Achievements |
In this study, 1) screening for microbial inhibitors of lipid metabolism (neutral lipids; cholesteryl ester (CE) and triglyceride (TG)), 2) in vivo test of pyripyropene A derivative, highly SOAT2 selective inhibitor, using a mouse model of fatty liver diseases (NAFLD/NASH) and 3) search for the mode of action of new microbial inhibitors of lipid metabolism (from 1)) and beauveriolide III, SOAT1-selective inhibitor in intact cells, using biochemistry techniques were investigated.
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