Development of signal amplification probes for detection of Copper (II) ions Using 11B NMR/MRI
| Project/Area Number |
16K18915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | The Noguchi Institute |
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Principal Investigator |
Tanaka Tomohiro 公益財団法人野口研究所, 研究部, 研究員 (20711667)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ホウ素MRI / カルボラン / 銅(II)イオン / 薬学 / 銅イオン検出 / ホウ素クラスター |
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| Outline of Final Research Achievements |
Biorelevant metals have been known to play an important role for bio-organism. Specifically, Cu2+ ion is closely correlated with certain types of physiological and pathological events. Therefore, the development of a noninvasive methodology for detecting Cu2+ is important for understanding its biological role and relationship with disease. Herein, we report on the development of a Cu2+‐specific 11B NMR/MRI probe. The method is based on the rapid complete deboronation reaction of nido-o-carborane containing a chelator unit by Cu2+ under physiological conditions.
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Report
(3 results)
Research Products
(7 results)
