Development of IgE-producing B-cell targeting peptide to treat pollen allergy
| Project/Area Number |
16K18917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyoto University (2017)
National Institute of Advanced Industrial Science and Technology (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アレルギー / ファージディスプレイ / 花粉症 / 薬学 |
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| Outline of Final Research Achievements |
Recently, the number of patients with allergic diseases such as pollen allergy have been increasing. Immunoglobulin E (IgE) is a main cause of those allergic diseases. In this study, we applied phage display system to determine the peptide sequences having the affinity to IgE. When we screened against IgE from human myeloma U266 cells, we obtained peptides with highly shared sequences. In contrast, total IgE was not changed in vivo when the allergic mice were injected with IgE-binding peptides.
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Report
(3 results)
Research Products
(4 results)
