Molecular machinery of viral pre-initiation complex in KSHV replication
| Project/Area Number |
16K18925
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental and hygienic pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
FUJIMURO Masahiro 京都薬科大学, 細胞生物学分野, 教授
IZUMIYA Yoshihiro UC Davis Comprehensive Cancer Center, Dermatology, Associate Professor
ITO Akihiro 東京薬科大学, 生命科学部・細胞情報学科学研究室, 教授
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | カポジ肉腫関連ヘルペスウイルス / ヘルペスウイルス / 遺伝子発現制御 / ウイルス性前開始複合体 / ウイルス / 感染症 / 発現制御 |
|---|
| Outline of Final Research Achievements |
In the cell of eukaryote including homo sapience, pre-initiation complex consists of TATA box binding protein, general transcription factors and RNA polymerase II initiates transcription for RNA production from its genome. Recently, It has been revealed that partial herpesviruses including Kaposi’s sarcoma-associated herpesvirus (KSHV) posses viral protein complex having functional homology to pre-initiation complex of eukaryote. The viral protein complex is called as “viral pre-initiation complex (vPIC)” and contributes to viral gene transcription. This study cleared that KSHV coding gene ORF34 and ORF66 are essential for efficient virus production via viral late gene expression. Furthermore, our results showed that both of them function as the component of vPIC.
|
Report
(3 results)
Research Products
(39 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] KSHV chromatin looping facilitates effective gene expression ; gene cluster activation via direct K-RTA binding at a viral chromatin hub2016
Author(s)
Mel Campbell, Tadashi Watanabe, Kazushi Nakano, Christopher Chen, Ryan Davis, Clifford G.Tepper, Masahiro Fujimuro, Yoshihiro Izumiya
Organizer
19th International Workshop on Kaposi’s Sarcoma Herpesvirus (KSHV) and related Agents
Place of Presentation
University of Southern California, Los Angeles, CA, U.S.A.
Year and Date
2016-07-19
Related Report
Int'l Joint Research
-
-
-
-
-
-
