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Improvement of oral delivery of hybrid peptide using absorption enhancer

Research Project

Project/Area Number 16K18937
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionMie University (2017)
Kyoto University (2016)

Principal Investigator

Gaowa Arong  三重大学, 医学系研究科, 助教 (50643805)

Research Collaborator HORIBE TOMOHISA  京都大学, 大学院医学研究科, 特定准教授 (20467468)
KOHNO MASAYUKI  京都大学, 大学院医学研究科, 特定講師 (00437203)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords薬物動態学 / ペプチド / ドラッグデリバリー / 経口製剤 / ドラックデリバリー
Outline of Final Research Achievements

The aim of this study was to improve the oral absorption of epidermal growth factor receptor (EGFR)-targeted hybrid peptide (EGFR2R-lytic) using bile acid as an absorption enhancer. The oral formulation of peptide was formed through the electrostatic interaction between the cationic peptide and anionic bile acid. In Caco-2 cell monolayers, absorption permeability of peptide from the peptide formulation was significantly increased compared with that of peptide alone. Furthermore, oral administration of peptide formulation to xenograft nude mouse showed significantly improved anti-tumor activity compared to free peptide. These results suggested that the bile acid is an effective absorption enhancer for improving the oral bioavailability and bioactivity of hybrid peptide.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Bile acid as an effective absorption enhancer for oral delivery of epidermal growth factor receptor targeted hybrid peptide2018

    • Author(s)
      Gaowa, A., Horibe, T., Kohno, M., Kawakami, K
    • Journal Title

      J Pharm Sci

      Volume: 107 Issue: 5 Pages: 1322-1329

    • DOI

      10.1016/j.xphs.2017.12.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of molecular targeted anti-cancer hybrid peptide for novel cancer therapy2017

    • Author(s)
      堀部 智久、河野 雅之、瀬戸 佳穂里、阿栄高娃、川上 浩司
    • Journal Title

      生化学

      Volume: 89 Issue: 1 Pages: 31-38

    • DOI

      10.14952/SEIKAGAKU.2017.890031

    • ISSN
      0037-1017
    • Year and Date
      2017-02-25
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Improvement of oral delivery of EGFR-targeted hybrid peptide by combination with bile acid.2017

    • Author(s)
      Gaowa. A., Horibe, T., Kohno, M., and Kawakami, K.
    • Organizer
      The 12th Australian Peptide Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] IMPROVEMENT OF ORAL DELIVERY OF EGFR-TARGETED HYBRID PEPTIDE USING ABSORPTION ENHANCER2016

    • Author(s)
      Arong Gaowa (他3名)
    • Organizer
      第53回日本ペプチド討論会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] EGFR-targeted hybrid peptide reduces tumor growth and prolongs survival of mice with metastatic liver cancer2016

    • Author(s)
      Arong Gaowa (他5名)
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィク横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Bile acid as an effective absorption enhancer for oral delivery of hybrid peptide2016

    • Author(s)
      Arong Gaowa (他3名)
    • Organizer
      The 34th European Peptide Symposium & The 8th International Peptide Symposium
    • Place of Presentation
      Leipzig University, Leipzig, Germany
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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