Pharmacokinetic analysis for TDM of anti-HIV drug dolutegravir.
Project/Area Number |
16K18938
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 抗HIV薬 / TDM / 薬物動態 / 個別化医療 / エイズ / LC/MS/MS / アドヒアランス / トランスポータ |
Outline of Final Research Achievements |
In current study, we tried to identify pharmacokinetic regulatory factors of the integrase inhibitor dolutegravir with the aim of accumulating basic information for Therapeutic Drug Monitoring (TDM) of anti-HIV drugs. As a result, it became clear that dolutegravir will serve as a substrate for BCRP, an efflux transporter. It was suggested that BCRP is involved as one of pharmacokinetic regulators of dolutegravir, and obtained a useful finding for the development to clinical studies using the human blood sample in the future.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] LC/QTOF‐MSによるフィルグラスチムバイオ後続品の定性・成分分析2016
Author(s)
松村健吾, 大谷祐基, 大村友博, 米澤淳, 津田真弘, 池見泰明, 中川俊作, 今井哲司, 中川貴之, 矢野育子, 吉貴達寛, 松原和夫
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Journal Title
医療薬学
Volume: 42
Pages: 613-619
NAID
Related Report
Peer Reviewed
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[Presentation] 生体肝移植術後のタクロリムス静脈内投与から経口投与への切り替え換算量に関する検討2016
Author(s)
都築徹教, 矢野育子, 中川俊作, 杉本充弘, 佐藤裕紀, 津田真弘, 上杉美和, 岡島英明, 海道利実, 上本伸二, 松原和夫
Organizer
第33回日本TDM学会・学術大会
Place of Presentation
栃木県総合文化センター(栃木県宇都宮市)
Year and Date
2016-05-28
Related Report