| Project/Area Number |
16K18988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Aki Sho 金沢大学, 医学系, 助教 (80767210)
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| Research Collaborator |
Azadul Sarker Kabir
Khin Aung Thuzar
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | PI3K / ホスホイノシタイド / エンドサイトーシス / 血管新生 / PI3キナーゼ / 細胞内小胞輸送 / 血管内皮細胞 / 生理学 |
|---|
| Outline of Final Research Achievements |
The phosphatidylinositol (PtdIns) 3-kinase (PI3K) family, which comprises three classes, regulates diverse cellular processes. In contrast to the well characterized class I and class III PI3Ks, physiological roles of class II PI3Ks were not well understood. We have recently demonstrated that class II α isoform (PI3K-C2α plays crucial roles in angiogenesis, by analyzing PI3K-C2α KO mice. PI3K-C2α which generates PI(3)P and PI(3,4)P2, plays crucial roles in angiogenesis. PI3K-C2α was found to be required for endocytosis and signaling of the receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor-2, the G protein-coupled receptor sphingosine-1-phosphate receptor-1 and serine/threonine kinase receptor TGFβ receptor. This study show that not only PI3K-C2α but also specific PI 5-phosphatase and PI 4-phosphatase required for receptor endocytosis via phosphoinositides metabolism.
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