Class II PI3K regulate receptor endocytosis and endosomal signaling
| Project/Area Number |
16K18988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Aki Sho 金沢大学, 医学系, 助教 (80767210)
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| Research Collaborator |
Azadul Sarker Kabir
Khin Aung Thuzar
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | PI3K / ホスホイノシタイド / エンドサイトーシス / 血管新生 / PI3キナーゼ / 細胞内小胞輸送 / 血管内皮細胞 / 生理学 |
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| Outline of Final Research Achievements |
The phosphatidylinositol (PtdIns) 3-kinase (PI3K) family, which comprises three classes, regulates diverse cellular processes. In contrast to the well characterized class I and class III PI3Ks, physiological roles of class II PI3Ks were not well understood. We have recently demonstrated that class II α isoform (PI3K-C2α plays crucial roles in angiogenesis, by analyzing PI3K-C2α KO mice. PI3K-C2α which generates PI(3)P and PI(3,4)P2, plays crucial roles in angiogenesis. PI3K-C2α was found to be required for endocytosis and signaling of the receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor-2, the G protein-coupled receptor sphingosine-1-phosphate receptor-1 and serine/threonine kinase receptor TGFβ receptor. This study show that not only PI3K-C2α but also specific PI 5-phosphatase and PI 4-phosphatase required for receptor endocytosis via phosphoinositides metabolism.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells2018
Author(s)
Pham Quynh Hoa, Yoshioka Kazuaki, Azadul Sarker Kabir, Aung Thuzar Khin, Islam Shahidul, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko1, Takuwa Yoh
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Journal Title
The Journal of Physiological Sciences
Volume: 68
Related Report
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