| Project/Area Number |
16K19008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Umemura Yasuhiro 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40612734)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 体内時計 / がん / 細胞分化 / 発生・分化 / 癌 / 遺伝子 |
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| Outline of Final Research Achievements |
In various human cancer cell lines, some cell lines showed the robust circadian rhythms and other cell lines showed the disruption of the circadian rhythms. Next, I investigated the mechanisms that disrupt circadian rhythms in these human cancer cell lines. The gene expressions of core circadian clock genes showed the similar expression levels in these cell lines, which cannot explain the mechanisms of the circadian clock disruption. Next, I analyzed the whole gene expression levels in these cell lines. The gene expression levels are compared with our previous extracted gene set by using mouse ES cells.
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