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Identification and functional analysis of a novel Nectin-mediated cell-adhesion apparatus

Research Project

Project/Area Number 16K19035
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionKyoto University

Principal Investigator

Maruoka Masahiro  京都大学, 物質-細胞統合システム拠点, 特定助教 (70736412)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsネクチン / 細胞間接着 / シグナル伝達
Outline of Final Research Achievements

The aim of this study is to undestand the role of Nectin-mediated cell-adhesion apparatus in mammary gland and to identify a novel Nectin-mediated cell-adhesion apparatus that contributes to the formation of functional tissue architecture other than mammary glands. I demonstrated that the Nectin-mediated cell-adhesion apparatus in the mammary gland interacts with the prolactin receptor essential for mammary gland development during pregnancy, thereby promoting the prolactin receptor signaling and revealed its molecular mechanism. In addition, using reporter mice that can visualize the expression of nectins, I identified a novel nectin-dependent cell adhesion apparatus.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Roles of the third Ig-like domain of Necl-5/PVR and the fifth Ig-like domain of the PDGF receptor in its signaling2018

    • Author(s)
      Ueda Yuki、Kedashiro Shin、Maruoka Masahiro、Mizutani Kiyohito、Takai Yoshimi
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 3 Pages: 214-224

    • DOI

      10.1111/gtc.12564

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.2017

    • Author(s)
      Maruoka, M., Kedashiro, S., Ueda, Y., Mizutani, K., and Takai, Y.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 17 Pages: 6895-6909

    • DOI

      10.1074/jbc.m116.769091

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nectin-like molecule-4/cell adhesion molecule 4 inhibits the ligand-induced dimerization of ErbB3 with ErbB22017

    • Author(s)
      Mizutani Kiyohito、Kedashiro Shin、Maruoka Masahiro、Ueda Yuki、Takai Yoshimi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 11375-11375

    • DOI

      10.1038/s41598-017-10107-5

    • NAID

      120006373795

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Nectin-mediated Cell Adhesion Apparatus Which Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development2016

    • Author(s)
      Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 11 Pages: 5817-5831

    • DOI

      10.1074/jbc.m115.685917

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] FUNCTIONAL ANALYSIS OF NECTINS IN MOUSE SUBMANDIBULAR GLANDS2017

    • Author(s)
      M. Kitayama, K. Mizutani, M. Maruoka, H. Suzuki, Y. Takai, T. Komori
    • Organizer
      23rd international Conference on Oral and Maxillofacial Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳腺分化における細胞間接着分子ネクチンの機能2017

    • Author(s)
      圓岡 真宏, 水谷 清人, 慶田城 迅, 高井 義美
    • Organizer
      第64回 日本生化学会 近畿支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ネクチン-4はSOCS1によるフィードバック阻害を抑制することで乳腺分化におけるプロラクチン受容体シグナル伝達を促進する2017

    • Author(s)
      圓岡 真宏, 水谷 清人, 慶田城 迅, 高井 義美
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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