| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we found that intracellular tau aggregation was associated by selective-autophagy chaperon p62. P62-mediated tau aggregates were secreted to extracellular space depend on autophagy activity. And we succeeded in the generation of tau pathology transmission model based on our WT htau-Tg mouse. Furthermore, we found that the well-known drug “rifampicin” works as the autophagy restoration agent and the intranasal administration of rifampicin shows highly protective effects on the phenotypes of Alzheimer’s disease model mouse.
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