Study of lipid metabolism by Bcl6 and application for drug discovery

Research Project

Project/Area Number	16K19060
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pathological medical chemistry
Research Institution	Tokai University
Principal Investigator	CHIKADA Hiromi 東海大学, 医学部, 特定研究員 (60712776)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	Bcl6 / 性差 / 薬物代謝 / 脂質代謝 / 脂質代謝異常 / 高脂肪食負荷 / 非アルコール性脂肪性肝炎 / エストロゲン
Outline of Final Research Achievements	B cell lymphoma 6 (Bcl6) is one of the key factors to regulate the sex specificity of the gene expression profiles or lipid metabolism in livers. We tried to confirm the Bcl6 function in the sex specificity of the Cytochrome P450 gene expression profiles. The expression of the male biased Cyps such as Cyp2d9 was decreased in Bcl6-LKO mice livers. The expression of the female biased Cyps such as Cyp3a41 was increased in Bcl6-LKO mice livers. These results suggested that Bcl6 was indispensable to regulate the sex specific expression of Cyps. We began to study the Bcl6 function in lipid metabolism and dyslipidemia and these sex specificities in livers.

Report

(3 results)