Microenviroment formation of gastric poorly differentiated adenocarcinoma is based on the regulation of clock genes.
| Project/Area Number |
16K19072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
Hirai Hideaki 東京医科大学, 医学部, 助教 (00770744)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 胃癌 / 食道癌 / 唾液腺導管癌 / 癌微小環境 / 時計遺伝子 / DEC / AR / HER2 |
|---|
| Outline of Final Research Achievements |
By focusing on the amount of stromal component, we subclassified the poorly differentiated gastric adenocarcinoma of solid type into the two groups: medullary carcinoma and non-medullary carcinoma. The medullary carcinomas less frequently displayed lymphatic invasion, venous invasion, and lymph node metastasis, compared with the non-medullary carcinoma. The patients with medullary carcinomas significantly showed better disease-free survival.
Furthermore, alterations in expression of apoptosis-related markers in human esophageal squamous cell carcinoma TE-11 cells treated with cisplatin were examined by western blot, while overall cell viability and apoptosis were analyzed by MTS assay and hematoxylin and eosin staining, respectively. We showed DEC2 exhibits anti-apoptotic effects in TE-11 esophageal squamous cell carcinoma cells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、胃や食道などの消化器癌における癌微小環境や、時計遺伝子発現の役割の一部を明らかにした。消化器癌ではDEC2を抑制することでアポトーシスが促進されるため、DEC2が治療標的になりうることが示唆された。これらの研究成果は、消化器癌の新たな治療戦略の構築に寄与するものと考えられる。
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Report
(4 results)
Research Products
(27 results)
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[Presentation] 唾液腺導管癌における重要な治療標的分子の遺伝子変異と蛋白発現 その予後・組織発生との関連2018
Author(s)
志村 智隆, 多田 雄一郎, 川北 大介, 塚原 清彰, 加納 里志, 清水 顕, 今西 順久, 大上 研二, 佐藤 雄一郎, 平井 秀明, 長尾 俊孝, 小林 一女
Organizer
日本耳鼻咽喉科学会
Related Report
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[Presentation] Novel approach for unresectable salivary duct carcinoma: Targeting HER2 and androgen receptor2018
Author(s)
Daisuke Kawakita, Yuichiro Tada, Chihiro Fushimi, Hideaki Takahashi, Tatsuo Masubuchi, Kouki Miura, Satoshi Kano, Kiyoaki Tsukahara, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Akira Shimizu, Yorihisa Imanishi, Toyoyuki Hanazawa, Mizuo Ando, Hideaki Hirai, Toshitaka Nagao
Organizer
American Society of Clinical Oncology Annual Meeting
Related Report
Int'l Joint Research
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