| Project/Area Number |
16K19079
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Japanese Foundation for Cancer Research (2018)
Nagoya University (2016-2017) |
|---|
Principal Investigator |
Yamashita Kyoko 公益財団法人がん研究会, がん研究所 病理部, 研究員 (50754975)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 脱分化型脂肪肉腫 / カスタムCGHアレイ / 予後因子 / カスタムアレイ / 病理学 / マイクロアレイ |
|---|
| Outline of Final Research Achievements |
For the purpose of clarifying the factors related to the distant metastasis and poor prognosis in dedifferentiated liposarcoma, array CGH analysis and clinicopathological analysis were performed. We used a custom CGH array, which included dense coverage for genes in the areas known to be frequently amplified in dedifferentiated liposarcoma. As a result, High MDM2/HMGA2 ration in array CGH and histological grade, cellular atypia and MDM2 immunoreactivity in pathological analysis proved to be important prognostic factors.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究によって明らかになった予後予測因子は、個々の患者の予後予測に有用であるばかりでなく、MDM2/HMGA2比が予後と関連するという結果は、脱分化型脂肪肉腫の病態解明の一助となり、また免疫染色上MDM2の発現が高いほど予後不良であるという結果は、治療薬の開発にも糸口を提供するものである。
|
